Dorothy K Hatsukami, Ph.D.
|Dorothy Hatsukami, Ph.D. is currently the Associate Director of Cancer Prevention
and Control for the Masonic Cancer Center, University of Minnesota, a Forster Family
Chair in Cancer Prevention, a Professor of Psychiatry and Adjunct Professor of
Psychology and of Epidemiology at the University of Minnesota, and the Director of the
Tobacco Research Programs.
Dr. Hatsukami is known for her research in the areas of nicotine addiction and treatment of nicotine addiction among a general population of adult smokers as well as adolescents. She has also conducted research in the area of smokeless tobacco. Her most recent research has primarily been focused on developing methods and measures to evaluate tobacco products and she has led an effort to develop a trandisciplinary team (both institutionally and nationally) around this topic. She has also concentrated her efforts on exploring and developing the science base for policies that might reduce tobacco-caused death and disease such as reducing the toxicity and nicotine in tobacco products.
Because of her expertise, Dr. Hatsukami has served on a number of national committees including the National Advisory Council for Substance Abuse and Mental Health Services Administration, National Advisory Council on Drug Abuse, the Interagency Committee for Smoking and Health, Drug Control Research, Data, and Evaluation Committee for the Office of National Drug Control Policy, the Institute of Medicine and on the Scientific Board of Counselors for the Intramural Research Program of NIDA. She has also served on the Tobacco Product Scientific Advisory Committee for the Food and Drug Administration. She has served on many advisory panels for other federal, non- profit and international organizations. She is a past president of the Society on Research on Nicotine and Tobacco and a past president of the College on Problems of Drug Dependence.
Alicia Allen, Ph.D., MPH
|Dr. Alicia Allen is an Assistant Professor in the Department of Family Medicine & Community Health. She has worked with Tobacco Research Programs since 2001. During this time, she completed her Masters of Public Health (2006), and Doctorate in Social & Behavioral Epidemiology (2012). She also completed a research fellowship on the topic of prenatal smoking in the Division of Reproductive Health at the Center for Disease Control and Prevention (CDC) in Atlanta, Georgia. Dr. Allen is interested in how sex hormones (such as progesterone and allopregnanolone) influence smoking behavior and smoking cessation outcomes. She is currently funded by grants from the National Institutes of Health, National Institute on Drug Abuse and the Office of Research on Women's Health.|
Sharon Allen, M.D., Ph.D.
Dr. Sharon Allen is a Professor of Family Medicine in the University of Minnesota
Medical School. She currently is doing research in smoking cessation and women,
teaches in the medical school and sees patients in the Primary Care Clinic and University
Specialists in Women's Health Clinic where she focuses on osteoporosis.
She received her PhD from Penn State University and then went on to do a postdoctoral fellowship at the University of Rochester Medical School in neuroendocrine research. During this time, she developed an interest in medicine and eventually attended the University of Rochester Medical School and was subsequently trained in Family Medicine. Over the last 20 years, she has been doing clinical research in this area with a specific focus on effects of hormones on smoking cessation and relapse. She was awarded an R01 from NIDA in 1991 and has had continued renewal of this grant for more than 20 years. The focus of this study has been the effect of menstrual cycle in smoking cessation in women, specifically looking at sex hormones. Most recently, she has been investigating smoking behavior in women on exogenous hormones and during pregnancy, the effect of exogenous hormones on smoking cessation outcomes in men and women, and exercise as a smoking cessation intervention in postmenopausal women.
|Stephen S. Hecht, Ph.D.|
Stephen S. Hecht, Ph.D. is currently a Wallin Land Grant Professor of Cancer Prevention
in the Department of Laboratory Medicine and Pathology and the Masonic Cancer
Center. Dr. Hecht received his Ph.D. from the Massachusetts Institute of Technology
where he also did postdoctoral research. He was previously Director of Research at the
American Health Foundation, a cancer prevention research institute.
The Hecht laboratory focuses on mechanisms and prevention of tobacco-induced cancer. The goal of their research is to understand mechanisms by which carcinogens are metabolically activated and detoxified in humans, and use this knowledge to develop practical strategies for cancer prevention, including the identification of individuals particularly susceptible to the carcinogenic effects of tobacco products. His group studies carcinogens that are present in tobacco products, the human diet, and the general environment; particular focus is on nitrosamines, aldehydes, and polycyclic aromatic hydrocarbons. Studies in laboratory animals are used to understand metabolic pathways. Then methods are developed to quantify metabolism of these carcinogens in humans, typically by employing GC-MS/MS, LC-MS/MS, or related methods to analyze carcinogen metabolites in urine, or carcinogen DNA or protein adducts in tissue or blood. These methods are applied in molecular epidemiology studies designed to determine factors that influence susceptibility to cancer development in exposed humans and in investigations of secondhand tobacco smoke exposure. Naturally occurring compounds that can prevent the metabolic activation of carcinogens or enhance their detoxification are also investigated. Mechanisms by which these chemopreventive agents act are determined in laboratory animals, then investigated in humans to investigate potential efficacy in cancer prevention.
|Michael Kotlyar, Pharm.D.|
Michael Kotlyar, Pharm.D. is an Associate Professor in the Department of Experimental
and Clinical Pharmacology. Dr. Kotlyar received his Doctorate of Pharmacology at
Purdue University, Lafayette, IN and completed a Fellowship at University of North
Carolina School of Pharmacy.
Dr. Kotlyar's current research interests include psychopharmacology with an emphasis on the pharmacokinetics of psychoactive medications, their effect on the physiologic response to mental stress and pharmacological interventions to facilitate smoking cessation.
Sharon Murphy, Ph.D.
Sharon Murphy, Ph.D. is a professor in the Department of Biochemistry, Molecular
Biology and Biophysics and the Director of Graduate Studies BMBB Graduate Program.
Dr. Murphy received her Doctorate from the University of Colorado.
Her research interest include nicotine metabolism in smokers and are on-going to investigate the influence of individual differences in nicotine metabolism on smoking behavior and nicotine dependence. Her studies in the laboratory have characterized P450 2A6 and P450 2A13-catalyzed metabolism of both nicotine and cotinine. P450 2A6, which is present in human liver is 94% identical to the extrahepatic enzyme, P450 2A13 found in the lung. Recently her laboratory determined that both enzymes are inactivated during nicotine metabolism, and are investigating the mechanism of this inactivation. P450 2A6 and P450 2A13 are also catalysts of the metabolic activation of the tobacco specific carcinogens NNN and NNK. However, despite the similarity of these two enzymes, they catalyze NNK metabolism with strikingly different efficiencies. Metabolism by site directed mutagens of these two enzymes are being studied to investigate these structure activity relationship. Polymorphisms of both P450 2A6 and P450 2A13 exist and her laboratory and others are studying the influence of enzyme variants on nicotine and nitrosamine metabolism.
|Irina Stepanov, Ph.D.|
Irina Stepanov , Ph.D. is an Assistant Professor in the Division of Environmental Health
Sciences at the School of Public Health. Dr. Stepanov received her Ph.D. in Chemistry
from Moldova State University (Republic of Moldova). She completed postdoctoral
training in the laboratory of Dr. Stephen Hecht at the University of Minnesota and
continued working as a research associate with Dr. Hecht at the Masonic Cancer Center.
Dr. Stepanov's research interests include the development of novel biomarkers of human exposure to chemical carcinogens; carcinogen-induced damage to chromosomal and mitochondrial DNA; application of biomarkers to understand inter-individual differences in susceptibility to chemical carcinogen-induced cancer; tobacco carcinogenesis.
|Amanda Anderson is a Community Program Specialist for the University of Minnesota's
Tobacco Research Programs. Amanda is a graduate of the University of Minnesota
with a BA in Psychology and has been working in the field of nicotine and tobacco
dependence since 1994. Amanda has coordinated numerous Smoking Cessation and
Harm Reduction Trials and has spent over 10 years in the area of treating smokeless
|Elizabeth Ford is a Community Program Specialist working for the University of
Minnesota-Duluth Medical School's Department of Behavioral Sciences. She also works
with the Tobacco Research Programs on the Twin Cities campus. She received a B.A.
in psychology from Smith College and is now working on a Masters in Public Health at
the University of Minnesota. Her research with the U of M has included topics related to
smoking and stress, smoking cessation and physical activity, and cancer prevention.|
|Katherine (Kat) Harrison, MPH|
|Kat Harrison has been working as a study coordinator for Tobacco Research Programs
since 2010. Her work at the University of Minnesota has included research related to the
use of exercise and relaxation as a smoking cessation tool. She completed her Masters
of Public Health 2008. Before working with the University of Minnesota's Tobacco
Research Programs, Kat worked as an epidemiologist in both Maine and the City of
|Louise Hertsgaard, MA, TTS|
|Louise Hertsgaard received a M.A. in Developmental Psychology at University of
Minnesota, 2007 and was certified as a Tobacco Treatment Specialist, Mayo Clinic
Nicotine Dependence Center, 2008. Currently, she is a clinical research coordinator
for the Tobacco Research Programs at the University of Minnesota. Since 2005 she has
coordinated studies using oral tobacco and reduced nicotine content cigarettes to help
people quit smoking.|
|Lindsay Jarvis (Farnsworth), TTS|
|Lindsay Jarvis is a certified Tobacco Treatment Specialist (T.T.S.), a certified basic
phlebotomist, and the study coordinator for the Hormones & Smoking Cessation
study. Lindsay graduated from the University of Wisconsin - Milwaukee with a B.S. in
Kinesiology and she is currently working towards her Masters in Public Health degree
here at the University of Minnesota. Lindsay is also a lifestyle coach for the YMCA
Diabetes Prevention Program.|
|Joni Jensen, MPH|
|Joni Jensen is the Tobacco Research Programs Clinic Manager. She is responsible for
the administration of Dr. Dorothy Hatsukami and Dr. Stephen Hecht's research projects
and is also responsible for regulatory oversight. She has worked in the tobacco research
area for the past 25 years. Please contact her with any questions or concerns about the
Tobacco Research Programs projects or staff.|
|Alex Johnson is a Community Programs Specialist with the Tobacco Research Programs. Alex is a graduate of Cornell College with a BA in Psychology and Mathematics with research interests in the cognition and decision making processes and effects of tobacco use. Alex's roles on the research team include research assistance as well as data, technology, and information systems management.|
|Kathy Longley is the Executive Assistant to Dorothy Hatsukami, Director of Tobacco
Research Programs. She has worked in the Tobacco Research Programs at the University
of Minnesota since 1989. In addition to her duties as Dr. Hatsukami's assistant, Kathy
also coordinates meetings and seminars for the Tobacco Research Programs as well as
the Prevention and Etiology Program in the Masonic Cancer Center.|
|Annie Mills, MPH|
|Annie Mills started working with the Tobacco Research Programs in 2011. She began
working as an exercise and relaxation therapist and has since taken on a role as a study
coordinator. Annie graduated from Carleton College with a Bachelor of Arts and
graduated from the University of Minnesota with a Masters Degree in Public Health.|
|Lor Moua has been working with the Tobacco Research Programs for the last 3 years.
He is currently working towards a Masters Degree in Public Health at the University of
|Jane Schulz, MPH, RN, CNP|
|Jane Schulz is an adult nurse practitioner who received her BSRN
at the U of MN School of Nursing, her nurse practitioner degree at the College of St
Catherine in St Paul, and her MPH in Maternal-Child Health at the U of MN School
of Public Health. She has worked as a nurse practitioner at the Minneapolis Schools'
school-based clinics, the MN Department of Health, Hennepin County's Health Care
for Homeless Program, the HIV care clinics in clinical care and research at both
Hennepin County Medical Center and the Delaware St Clinic, and the MN Perinatal HIV
Prevention Program. She has been employed at the Tobacco Research Program since
2008 providing physical examinations and health education for study participants in
tobacco and cocaine use research studies.|
|Elizabeth Thompson graduated from Iowa State University with a BS in Chemistry and is currently pursuing a Master's degree in Public Health at the University of Minnesota. Elizabeth splits her time as a study coordinator with the Tobacco Research Programs and in the laboratory in the Cancer Center working on nicotine metabolism studies.|
|Nicole Tosun, MS, TTS|
|Nicole Tosun is a Clinical Research Coordinator and has been with Tobacco Research
Programs since 2010. During this time she completed training as a Certified Tobacco
Treatment Specialist (TTS), as well as, Certified Basic Phlebotomist. Before moving
to Minnesota Nicole earned a Master of Science degree in Research, Statistics, and
Measurement and a Bachelor of Arts in Psychology from Connecticut State University.
Nicole is interested in how sex hormones (such as progesterone and allopregnanolone)
effect smoking behavior and smoking cessation outcomes.|