Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

What is the purpose of the study? 

This study is examining how smoking a very low nicotine content (VLNC) cigarette compares to smoking a cigarette with levels of nicotine similar to brands currently on the market.  This study looks at whether you choose to use other nicotine products, like nicotine gum or patch, e-cigaretetes and vaping devices or smokelss tobacco products while you are assigned to the study cigarettes. 

How often are the clinic visits?

You will first attend a screening visit ot see if you are eligible.  If you are eligible after the screening visit, the research study will last 20 weeks.  During this time you will attend 14 visits; weekly visits for 8 weeks and then every other week for 8 weeks and a follow-up visit 1 month after the end of the intervention.  Each of the visits are between 1-2 1/2 hours. 

What will I be doing in the study?

You will complete questionnaires, have a breath test for carbon monoxide and alcohol levels and vital signs will be taken.  We will also collect urine samples from you.  Throughout the study, you will keep daily records of your tobacco use.  Lastly, you will exchanges points for study products including your assigned study cigarettes and other tobacco or nicotine containing products.

Will I be compensated?

If you agree to take  part in this research study, you could receive up to $1255.00 for your time and effort.  You will receive $40 for attending each study clinic visit and $10 for travel.  In addition, you will recieve $15 for the 7 visits when we collect first morning void urine samples and have additional questionnaires.  At the end of the study you will receive $10 for each week that you completed all of the daily phone calls.  If you have completed all of the study procedures and been honest about your tobacco and nicotine use, you will receive up to a $300 bonus at the end of the study. 

What should I do if I'm interested? 

If you would like to find out if you qualify for this study contact us at 612-625-1294 or email

We are looking for...

Men and women who currently smoke cigarettes who may or may not be interested in quitting, ages 18+, and who are in generally stable health.

Study Coordinator

If you would like to find out if you qualify for this study contact us at 612-625-1294 or email


Tobacco Research Programs
717 Delaware St SE
Minneapolis, MN 55414

Phone: 612-626-5155
Fax: 612-624-4610