Stress and Cannabis Use Primary (STOMP)

What is the purpose of the study?

The purpose of this study is to compare the physiological and subjective stress responses of those who use and those who do not use marijuana and nicotine. We also want to study how these responses to stress predict smoking relapse; and we want to learn if people who have difficulties in quitting show specific types of responses.

How often are the clinic visits?

We expect that you will be in this research study for approximately four months. This research study includes a medical screening visit (~2 hours), six counseling support sessions that will be built-in to the study visits, two laboratory visits (~3 hours per visit), four ambulatory visits (~1 hour per visit), four weekly followup visits (~1 hour per visit), and one three-month follow-up visit (~1 hour). Upon completing the medical screening, we will schedule your first two ambulatory visits and first laboratory visit during a 3-day period. The second three-day period of the next two ambulatory visits and second laboratory visit will be 2-3 weeks from the first one. Then we will see you for 1 weekly follow-up visit every week for a month and finally you will end with a three-month follow-up visit.

What will I be doing in the study?

You will be asked to complete two lab visits; and you will be asked to complete “ambulatory activities” prior to each lab visit, which include: (a) collecting your first void urine on the day of your lab visits and (b) collecting several saliva samples and completing questionnaires at designated time points during three-day periods prior to each of your lab visits, (c) completing a short interview and returning the samples and questionnaires to us every 24-hrs during the three-day periods. If you are a smoker, the first 3-day ambulatory period will take place when you are smoking as usual; and the second 3-day ambulatory period will begin on your smoking quit date. If you use marijuana regularly, the first 3-day ambulatory period will take place when you are using marijuana as usual. After the first lab visit, you will be assigned to one of two groups – either abstinence or usual use of marijuana during the second 3-day ambulatory. – You will not get to choose the group in which you are placed; your group placement will be selected randomly. Abstinence will be verified biochemically. After the second lab visit, you will be asked to complete daily diaries about your daily marijuana and nicotine use as well as your mood. You will also be asked to complete 5 follow-up visits that will take place 1 week, 2 weeks, 3 weeks, 4 weeks, and 3 months after you complete the second lab visit. At each follow-up visit, we will collect saliva and urine samples and we will measure your weight, blood pressure, heart rate, and expired carbon monoxide. We will also ask you about your mood; stress; cravings; and any medication, tobacco/nicotine, and marijuana use.

Will I be compensated?

If you agree to take part in this research study and complete all study procedures and activities, you will be eligible to receive a maximum payment of $650. 

What should I do if I’m interested?

Let us know by calling 612-625-6972 or emailing or Please leave your name and a contact number in your email or voicemail.




Study Coordinator

If you would like to find out if you qualify for this study please call 612-625-6972 or e-mail 


Tobacco Research Programs
717 Delaware St SE
Minneapolis, MN 55414

Phone: 612-626-5155
Fax: 612-624-4610